In vivo light dosimetry for pleural PDT

Andreea Dimofte; Timothy C. Zhu; Jarod C. Finlay; Melissa Culligan; Christine E. Edmonds; Joseph S. Friedberg; Keith Cengel; Stephen M. Hahn

doi:10.1117/12.809548

18 February 2009 In vivo light dosimetry for pleural PDT

Andreea Dimofte, Timothy C. Zhu, Jarod C. Finlay, Melissa Culligan, Christine E. Edmonds, Joseph S. Friedberg, Keith Cengel, Stephen M. Hahn

Author Affiliations +

Proceedings Volume 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII; 71640A (2009) https://doi.org/10.1117/12.809548
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

In-vivo light Dosimetry for patients undergoing photodynamic therapy (PDT) is one of the important dosimetry quantities critical for predicting PDT outcome. This study examines the light fluence (rate) delivered to patients undergoing pleural PDT as a function of treatment time, treatment volume and surface area, and its accuracy as a function of the calibration accuracies of each isotropic detector and the calibration integrating sphere. The patients studied here were enrolled in Phase II clinical trial of Photofrin-mediated PDT for the treatment of non-small cell lung cancer with pleural effusion. The ages of the patients studied varied from 34 to 69 year old. All patients were administered 2mg per kg body weight Photoprin 24 hours before the surgery. Patients undergoing photodynamic therapy (PDT) are treated with laser light with a light fluence of 60 J/cm^2 at 630nm. Fluence rate (mW/cm^2) and cumulative fluence (J/cm^2) was monitored at 7 different sites during the entire light treatment delivery. Isotropic detectors were used for in-vivo light dosimetry. The anisotropy of each isotropic detector was found to be within 30%. The mean fluence rate delivery varied from 37.84 to 94.05 mW/cm^2 and treatment time varied from 1762 to 5232s. We have established a correlation between the treatment time and the treatment volume. The results are discussed using an integrating sphere theory and the measured tissue optical properties. The result can be used as a clinical guideline for future pleural PDT treatment.

Citation Download Citation

Andreea Dimofte, Timothy C. Zhu, Jarod C. Finlay, Melissa Culligan, Christine E. Edmonds, Joseph S. Friedberg, Keith Cengel, and Stephen M. Hahn "In vivo light dosimetry for pleural PDT", Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640A (18 February 2009); https://doi.org/10.1117/12.809548

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