Prostate histotripsy for BPH: initial canine results

William W. Roberts; Timothy L. Hall; Christopher R. Hempel; Charles A. Cain

doi:10.1117/12.808516

23 February 2009 Prostate histotripsy for BPH: initial canine results

William W. Roberts, Timothy L. Hall, Christopher R. Hempel, Charles A. Cain

Proceedings Volume 7161, Photonic Therapeutics and Diagnostics V; 71611N (2009) https://doi.org/10.1117/12.808516
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Histotripsy is an extracorporeal ablative technology that utilizes microsecond pulses of intense ultrasound (< 1% duty cycle) to produce nonthermal, mechanical fractionation of targeted tissue. We have previously demonstrated the feasibility of histotripsy prostate ablation. In this study we sought to assess the chronic tissue response, tolerability and safety of histotripsy in a chronic in vivo canine model. Five acute and thirteen chronic canine subjects were anesthetized and treated with histotripsy targeting the prostate. Pulses consisted of 3 cycle bursts of 750 kHz ultrasound at a repetition rate of 300 Hz delivered transabdominally from a highly focused 15 cm aperture array. Transrectal ultrasound imaging provided accurate targeting and real-time monitoring of histotripsy treatment. Prostates were harvested at 0, 7, 28, or 56 days after treatment. Consistent mechanical tissue fractionation and debulking of prostate tissue was seen acutely and at delayed time points without collateral injury. Urothelialization of the treatment cavity was apparent 28 days after treatment. Canine subjects tolerated histotripsy with minimal hematuria or discomfort. Only mild transient lab abnormalities were noted. Histotripsy is a promising non-invasive therapy for prostate tissue fractionation and debulking that appears safe and well tolerated without systemic side effects in the canine model.

Citation Download Citation

William W. Roberts, Timothy L. Hall, Christopher R. Hempel, and Charles A. Cain "Prostate histotripsy for BPH: initial canine results", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71611N (23 February 2009); https://doi.org/10.1117/12.808516

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available