Wireless integrated microsystems for monitoring brain chemical and electrical activity

Masoud Roham; Paul A. Garris; Pedram Mohseni

doi:10.1117/12.796007

29 August 2008 Wireless integrated microsystems for monitoring brain chemical and electrical activity

Masoud Roham, Paul A. Garris, Pedram Mohseni

Proceedings Volume 7035, Biosensing; 70350O (2008) https://doi.org/10.1117/12.796007
Event: NanoScience + Engineering, 2008, San Diego, California, United States

Abstract

A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm² IC is fabricated using a 0.5-μm CMOS process and incorporates a 71-μW, 3rd-order, reconfigurable, ΔΣ modulator per channel, achieving an input-referred noise of 4.69 μV_rms in 4-kHz BW and 94.1 pA_rms in 5-kHz BW for electrical and fast-scan voltammetric chemical neurosensing, respectively. The chip has been externally interfaced with carbon-fiber microelectrodes implanted acutely in the caudate-putamen of an anesthetized rat, and, for the first time, extracellular levels of dopamine elicited by electrical stimulation of the medial forebrain bundle have been successfully recorded wirelessly across multiple channels using 300-V/s fast-scan cyclic voltammetry.

Citation Download Citation

Masoud Roham, Paul A. Garris, and Pedram Mohseni "Wireless integrated microsystems for monitoring brain chemical and electrical activity", Proc. SPIE 7035, Biosensing, 70350O (29 August 2008); https://doi.org/10.1117/12.796007

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