Time gating in glucose sensing with ultrashort pulses

Alexander V. Bykov; Mikhail Yu. Kirillin; Alexander V. Priezzhev; Risto Myllyla

doi:10.1117/12.804085

5 June 2008 Time gating in glucose sensing with ultrashort pulses

Alexander V. Bykov, Mikhail Yu. Kirillin, Alexander V. Priezzhev, Risto Myllyla

Proceedings Volume 7022, Advanced Laser Technologies 2007; 70220X (2008) https://doi.org/10.1117/12.804085
Event: Advanced Laser Technologies 2007, 2007, Levi, Finland

Abstract

The feasibility of the time-of-flight (TOF) technique application at the wavelength of 820 nm for the sensing the changes in optical properties of multilayered scattering medium is considered. The TOF signals from a 3-layer biotissue phantom consisting of two skin layers and a blood layer between them are obtained by using the Monte Carlo method for various values of glucose content. Glucose level variations in the physiological range of concentrations are supposed to induce changes in the optical properties of the blood-like layer and the bottom skin-like layer of the considered 3-layer phantom. Different characteristics of the obtained TOF signal are analyzed. Relative changes in the signals induced by the glucose level variations are analyzed for different source-detector separations. It is shown that the maximal relative change of the pulse energy corresponding to the glucose concentration change from 0 to 500 mg/dl is about 7%; however, the application of the time gating technique allows to increase this sensitivity up to 12 %. The sensitivity maps allowing to determin the optimal position and size of the time gate are obtained for five values of the source-detector separation.

Citation Download Citation

Alexander V. Bykov, Mikhail Yu. Kirillin, Alexander V. Priezzhev, and Risto Myllyla "Time gating in glucose sensing with ultrashort pulses", Proc. SPIE 7022, Advanced Laser Technologies 2007, 70220X (5 June 2008); https://doi.org/10.1117/12.804085

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