Cone beam CT tumor vasculature dynamic study (Murine model)

Dong Yang; Ruola Ning; David Conover; Betancourt Ricardo; Shaohua Liu

doi:10.1117/12.770762

3 April 2008 Cone beam CT tumor vasculature dynamic study (Murine model)

Dong Yang, Ruola Ning, David Conover, Betancourt Ricardo, Shaohua Liu

Proceedings Volume 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images; 691629 (2008) https://doi.org/10.1117/12.770762
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

Tumor angiogenesis is the process by which new blood vessels are formed from the existing vessels in a tumor to promote tumor growth. Tumor angiogenesis has important implications in the diagnosis and treatment of various solid tumors. Flat panel detector based cone beam CT opens up a new way for detection of tumors, and tumor angiogenesis associated with functional CBCT has the potential to provide more information than traditional functional CT due to more overall coverage during the same scanning period and the reconstruction being isotropic resulting in a more accurate 3D volume intensity measurement. A functional study was conducted by using CBCT to determine the degree of the enhancement within the tumor after injecting the contrast agent intravenously. For typical doses of contrast material, the amount of enhancement is proportional to the concentration of this material within the region of interest. A series of images obtained at one location over time allows generation of time-attenuation data from which a number of semi-quantitative parameters, such as enhancement rate, can be determined. An in vivo mice study with and without mammo tumor was conducted on our prototype CBCT system, and half scan scheme is used to determine the time-intensity curve within the VOI of the mouse. The CBCT has an x-ray tube, a gantry with slip ring technology, and a 40×30 cm Varian Paxscan 4030CB real time FPD.

Citation Download Citation

Dong Yang, Ruola Ning, David Conover, Betancourt Ricardo, and Shaohua Liu "Cone beam CT tumor vasculature dynamic study (Murine model)", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 691629 (3 April 2008); https://doi.org/10.1117/12.770762

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