Multi-parameter optical image interpretations based on self-organizing mapping

Christian D. Klose; A. K. Klose; U. Netz; A. Scheel; J. Beuthan; Andreas H. Hielscher

doi:10.1117/12.763680

7 March 2008 Multi-parameter optical image interpretations based on self-organizing mapping

Christian D. Klose, A. K. Klose, U. Netz, A. Scheel, J. Beuthan, Andreas H. Hielscher

Proceedings Volume 6850, Multimodal Biomedical Imaging III; 68500G (2008) https://doi.org/10.1117/12.763680
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

We found that using more than one parameter derived from optical tomographic images can lead to better image classification results compared to cases when only one parameter is used.. In particular we present a multi-parameter classification approach, called self-organizing mapping (SOM), for detecting synovitis in arthritic finger joints based on sagittal laser optical tomography (SLOT). This imaging modality can be used to determine various physical parameters such as minimal absorption and scattering coefficients in an image of the proximal interphalengeal joint. Results were compared to different gold standards: magnet resonance imaging, ultra-sonography and clinical evaluation. When compared to classifications based on single-parameters, e.g., absorption minimum only, the study reveals that multi-parameter classifications lead to higher classification sensitivities and specificities and statistical significances with p-values <5 per cent. Finally, the data suggest that image analyses are more reliable and avoid ambiguous interpretations when using more than one parameter.

Citation Download Citation

Christian D. Klose, A. K. Klose, U. Netz, A. Scheel, J. Beuthan, and Andreas H. Hielscher "Multi-parameter optical image interpretations based on self-organizing mapping", Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500G (7 March 2008); https://doi.org/10.1117/12.763680

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