The difference of the PDT's effects between interstitial lighting and continuous lighting in low oxygen density

Jiumin Yang; Yingxin Li; Tiegen Liu; Tao Xu

doi:10.1117/12.762375

12 February 2008 The difference of the PDT's effects between interstitial lighting and continuous lighting in low oxygen density

Jiumin Yang, Yingxin Li, Tiegen Liu, Tao Xu

Author Affiliations +

Proceedings Volume 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII; 684510 (2008) https://doi.org/10.1117/12.762375
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Tumor oxygen depletion plays an important role in the process of Photodynamic Therapy (PDT). The paper focuses on the improvement of the lighting mode to carry out this cancer therapy more effectively in low oxygen content. The effect of interstitial lighting was compared with that of continuous lighting in different oxygen density measured with a homemade device in PDT. 90 mice were divided into 3 groups: the contrast group, the continuous lighting group and the interstitial lighting group. The initial oxygen content was measured with a homemade device before the treatment. To examine the different effects, both the interstitial lighting and the continuous lighting have the same fluent rates (30mW/cm2, 32.4J/ cm2). The continuous lighting lasted 18 minutes while the interstitial lighting lasted 36 minutes with 1 second's idle time and 1 second's effective time of each pulse. The result shows that the volume of tumor doubling duration in interstitial lighting group is longer in the condition of low initial oxygen content. Thus with low initial oxygen content, the interstitial lighting is more effective than the continuous lighting during PDT.

Citation Download Citation

Jiumin Yang, Yingxin Li, Tiegen Liu, and Tao Xu "The difference of the PDT's effects between interstitial lighting and continuous lighting in low oxygen density", Proc. SPIE 6845, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVII, 684510 (12 February 2008); https://doi.org/10.1117/12.762375

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