Paper
27 December 2007 Design of painless microneedle for blood extraction system
Kazuyoshi Tsuchiya, Keisuke Isobata, Miho Sato, Yasutomo Uetsuji, Eiji Nakamachi, Kagemasa Kajiwara, Minoru Kimura
Author Affiliations +
Proceedings Volume 6799, BioMEMS and Nanotechnology III; 67990Q (2007) https://doi.org/10.1117/12.759058
Event: SPIE Microelectronics, MEMS, and Nanotechnology, 2007, Canberra, ACT, Australia
Abstract
The microneedle size mimicking a female mosquito's labium which almost collects blood painless is effective to mitigate the injection pain for patients. The author has produced the microneedle production technique which can produce arbitrary size. The microneedle production technique is to deposit the microneedle material on a rotating wire substrate by a sputtering deposition method and etch the wire substrate by a chemical solution after a heat treatment. In the result, a titanium microneedle was produced (outer and inner diameter : 50 μm and 25μm) in the size mimicking that of female mosquito's labium. The inner diameter for the needle is decreased when outer diameter is decreased, hence, the rigidity of the needle is decreased and the pressure drop by pipe friction is increased. Therefore, microneedles to be able to mitigate the pain for the patient and decrease the pressure drop by pipe friction should be designed. In this study, the outer and inner diameters of 50 μm and 25 μm are defined as the basic dimension of the microneedle. Those rigidity and pressure drop by pipe friction in "n" polygonal shape circumscribed and inscribed for basic dimension in the microneedle are calculated. The best shape with "n" polygonal shape to satisfy conditions that needle has rigidity enough to inject the skin without buckling and to decrease the pressure drop by pipe friction to be able to extract blood was searched. The pressure loss became small more than the negative pressure generated with SMA micro pump in n=6. Therefore, the microneedle with sexanglular shape(n=6) made by titanium(E=110.6GPa) can be injected into the skin without buckling and decreased the pressure drop by pipe friction.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kazuyoshi Tsuchiya, Keisuke Isobata, Miho Sato, Yasutomo Uetsuji, Eiji Nakamachi, Kagemasa Kajiwara, and Minoru Kimura "Design of painless microneedle for blood extraction system", Proc. SPIE 6799, BioMEMS and Nanotechnology III, 67990Q (27 December 2007); https://doi.org/10.1117/12.759058
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Cited by 5 scholarly publications.
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KEYWORDS
Blood

Skin

Shape memory alloys

Titanium

Liquids

Actuators

Metals

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