Optical spectroscopy for therapeutic guidance in breast conserving therapy

Matthew D. Keller; Shovan K. Majumder; Mark C. Kelley; Ingrid Meszoely; Fouad I. Boulos; Anita Mahadevan-Jansen

doi:10.1117/12.729529

11 July 2007 Optical spectroscopy for therapeutic guidance in breast conserving therapy

Matthew D. Keller, Shovan K. Majumder, Mark C. Kelley, Ingrid Meszoely, Fouad I. Boulos, Anita Mahadevan-Jansen

Proceedings Volume 6628, Diagnostic Optical Spectroscopy in Biomedicine IV; 66280J (2007) https://doi.org/10.1117/12.729529
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Most women with early breast cancer have the option of breast conserving therapy, which involves the complete removal of the primary breast lesion (a lumpectomy) with tumor-free margins, followed by radiotherapy. Since the presence of tumor at or near the margin is strongly correlated with the risk of local tumor recurrence, there is a need to develop a non-invasive, real-time tool that can differentiate normal breast tissue from tumor at the margins to assure complete removal. Our previous studies have demonstrated the ability of combined autofluorescence and diffuse reflectance spectroscopy to differentiate normal from non-normal breast tissue ex vivo. Using a portable, combined fluorescence and reflectance spectroscopy system, measurements were taken from each of the six surfaces of the tissue mass immediately following removal during lumpectomies for 24 patients. After correlation with histopathology, a multivariate statistical algorithm classified the 27 tumor spectra and 102 normal spectra with 78% sensitivity and 99% specificity, or 94% negative and 95% positive predictive value. Since point spectroscopy is ultimately insufficient for this application due to its small sampling area, fluorescence and reflectance spectral images from a lumpectomy specimen were gathered and used to show the feasibility of this approach.

Citation Download Citation

Matthew D. Keller, Shovan K. Majumder, Mark C. Kelley, Ingrid Meszoely, Fouad I. Boulos, and Anita Mahadevan-Jansen "Optical spectroscopy for therapeutic guidance in breast conserving therapy", Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66280J (11 July 2007); https://doi.org/10.1117/12.729529

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tumors

Tissues

Luminescence

Breast

Diffuse reflectance spectroscopy

Reflectivity

Tissue optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years