A new model for myosin dimeric motors incorporating Brownian ratchet and powerstroke mechanisms

Brian Geislinger; Ryoichi Kawai

doi:10.1117/12.724693

8 June 2007 A new model for myosin dimeric motors incorporating Brownian ratchet and powerstroke mechanisms

Brian Geislinger, Ryoichi Kawai

Proceedings Volume 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems; 660206 (2007) https://doi.org/10.1117/12.724693
Event: SPIE Fourth International Symposium on Fluctuations and Noise, 2007, Florence, Italy

Abstract

A new dimer model is introduced to describe the behavior of dimeric processive motor proteins in general. A single motor domain is modeled using our previous work on hybrid motors that exhibit elements of both a powerstroke and a Brownian motor mechanism. The different behavior observed in Myosins V and VI can be explained by varying the physical parameters describing the coupling between the two motor domains. The dynamics of the resulting stepping mechanics under loaded and unloaded conditions are examined. The results from this dimer model are compared with experimental data for two-headed processive motors.

Citation Download Citation

Brian Geislinger and Ryoichi Kawai "A new model for myosin dimeric motors incorporating Brownian ratchet and powerstroke mechanisms", Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 660206 (8 June 2007); https://doi.org/10.1117/12.724693

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