Ventrolateral prefrontal activation during a N-back task assessed with multichannel functional near-infrared spectroscopy

Yuan Zhou; Ye Zhu; Tianzi Jiang

doi:10.1117/12.741329

1 May 2007 Ventrolateral prefrontal activation during a N-back task assessed with multichannel functional near-infrared spectroscopy

Yuan Zhou, Ye Zhu, Tianzi Jiang

Author Affiliations +

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 65340K (2007) https://doi.org/10.1117/12.741329
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

Functional near-infrared spectroscopy (fNIRS) has been used to investigate the changes in the concentration of oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin in brain issue during several cognitive tasks. In the present study, by means of multichannel dual wavelength light-emitting diode continuous-wave (CW) NIRS, we investigated the blood oxygenation changes of prefrontal cortex in 18 healthy subjects while performing a verbal n-back task (0-back and 2-back), which has been rarely investigated by fNIRS. Compared to the 0-back task (control task), we found a significant increase of O2Hb and total amount of hemoglobin (THb) in left and right ventrolateral prefrontal cortex (VLPFC) during the execution of the 2-back task compared to the 0-back task (p<0.05, FDR corrected). This result is consistent with the previous functional neuroimaging studies that have found the VLPFC activation related to verbal working memory. However, we found no significant hemisphere dominance. In addition, the effects of gender and its interaction with task performance on O2Hb concentration change were suggested in the present study. Our findings not only confirm that multichannel fNIRS is suitable to detect spatially specific activation during the performance of cognitive tasks; but also suggest that it should be cautious of gender-dependent difference in cerebral activation when interpreting the fNIRS data during cognitive tasks.

Citation Download Citation

Yuan Zhou, Ye Zhu, and Tianzi Jiang "Ventrolateral prefrontal activation during a N-back task assessed with multichannel functional near-infrared spectroscopy", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65340K (1 May 2007); https://doi.org/10.1117/12.741329

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