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Prediction of blood glucose using interstitial fluid extracted by ultrasound and vacuum is proposed by the paper.
Low-frequency ultrasound with 55 KHz is applied for about 30 seconds to enhance the skin permeability to interstitial
fluid by disrupting the stratum corneum lipid bilayers and then interstitial fluid is extracted out of skin successfully by
10in.Hg vacuum for 15 minutes. The glucose concentration in the interstitial fluid is measured by an instrument with
immobilized enzyme sensor. And then a method of data analysis is set up to prediction the glucose concentration in the
blood by the measurement of the glucose concentration in the interstitial fluid. At last, Clarke Error Grid analysis is
performed to assess if the prediction accuracy could satisfy the requirements of clinical application. The whole method
and experimental system above is set up in the article and the feasibility of this way for blood glucose detecting is
primarily validated for clinical application with the requirements of bloodless, painless, continuous glucose monitoring.
Additional a prototype of miniature diabetes monitoring device with the technique of surface plasma resonance to
measure the glucose concentration in the interstitial fluid is also being developed.
Dachao Li,Haixia Yu,Xian Huang,Fuxiang Huang,Xiaotang Hu, andKexin Xu
"Prediction of blood glucose using interstitial fluid extracted by ultrasound and vacuum", Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 64450I (14 February 2007); https://doi.org/10.1117/12.699691
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