Airway morphometry in the lungs as depicted in chest CT examinations variability of measurements

J. Ken Leader; Bin Zheng; Frank C. Scuirba; Harvey O. Coxson; Joel L. Weissfeld; Carl R. Fuhrman; Glenn S. Maitz; David Gur

doi:10.1117/12.653984

13 March 2006 Airway morphometry in the lungs as depicted in chest CT examinations variability of measurements

J. Ken Leader, Bin Zheng, Frank C. Scuirba, Harvey O. Coxson, Joel L. Weissfeld, Carl R. Fuhrman, Glenn S. Maitz, David Gur

Author Affiliations +

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61432R (2006) https://doi.org/10.1117/12.653984
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

The purpose of the study was to decrease the variability of computed tomographic airway measurements. We to developed and evaluated a novel computer scheme to automatically segment airways depicted on chest CT examinations at the level of the lobar and segmental bronchi and to decrease. The computer scheme begins with manual selection of a seed point within the airway from which the airway wall and lumen are automatically segmented and airway pixels were assigned full or partial membership to the lumen or wall. Airway pixels not assigned full membership to the lumen (< -900 HU) or wall (> 0 HU) were assigned partial membership to the lumen and wall. In fifteen subjects with no visible signs of emphysema and a range of pulmonary obstruction from none to severe, airway measures were compared to pulmonary function parameters in a rank order analysis to evaluate measuring a single airway versus multiple airways. The quality of the automated airway segmentation was visually acceptable. The Pearson Correlation coefficients for the ranking of FEV₁ versus wall area percent (percent of total airway size) and FVC versus wall area percent were 0.164 and 0.175 for a single measurement, respectively, and were 0.243 and 0.239 for multiple measurements, respectively. Our preliminary results suggest that averaging the measurements from multiple airways may improve the relation between airway measures and lung function compared to measurement from a single airway, which improve quantification of airway remodeling in COPD patients.

Citation Download Citation

J. Ken Leader, Bin Zheng, Frank C. Scuirba, Harvey O. Coxson, Joel L. Weissfeld, Carl R. Fuhrman, Glenn S. Maitz, and David Gur "Airway morphometry in the lungs as depicted in chest CT examinations variability of measurements", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61432R (13 March 2006); https://doi.org/10.1117/12.653984

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available