Reliable long-term continuous blood glucose monitoring for patients in critical care using microdialysis and infrared spectrometry

H. Michael Heise; Uwe Damm; Venkata R. Kondepati

doi:10.1117/12.650833

27 February 2006 Reliable long-term continuous blood glucose monitoring for patients in critical care using microdialysis and infrared spectrometry

H. Michael Heise, Uwe Damm, Venkata R. Kondepati

Author Affiliations +

Proceedings Volume 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry; 609303 (2006) https://doi.org/10.1117/12.650833
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

For clinical research, in-vivo blood glucose monitoring is an ongoing important topic to improve glycemic control in patients with non-adequate blood glucose regulation. Critically ill patients received much interest, since the intensive insulin therapy treatment, as established for diabetics, reduces mortality significantly. Despite the existence of commercially available, mainly amperometric biosensors, continued interest is in infrared spectroscopic techniques for reagent-free glucose monitoring. For stable long-term operation, avoiding also sensor recalibration, a bed-side device coupled to a micro-dialysis probe was developed for quasi-continuous glucose monitoring. Multivariate calibration is required for glucose concentration prediction due to the complex composition of dialysates from interstitial body fluid. Measurements were carried out with different test persons, each experiment lasting for more than 8 hours. Owing to low dialysis recovery rates, glucose concentrations in the dialysates were between 0.83 and 4.44 mM. Standard errors of prediction (SEP) obtained with Partial Least Squares (PLS) calibration and different cross-validation strategies were mainly between 0.13 and 0.18 mM based on either full interval data or specially selected spectral variables.

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H. Michael Heise, Uwe Damm, and Venkata R. Kondepati "Reliable long-term continuous blood glucose monitoring for patients in critical care using microdialysis and infrared spectrometry", Proc. SPIE 6093, Biomedical Vibrational Spectroscopy III: Advances in Research and Industry, 609303 (27 February 2006); https://doi.org/10.1117/12.650833

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