Development of the optical biopsy system for small experimental animals

Hidetoshi Sato; Yusuke Hattori; Yusuke Oshima; Yuichi Komachi; Takashi Katagiri; Toru Asakura; Toru Shimosegawa; Yuji Matsuura; Mitsunobu Miyagi; Gen'ichi Kanai; Nobuo Ura; Koji Masutani; Hideo Tashiro

doi:10.1117/12.645842

22 February 2006 Development of the optical biopsy system for small experimental animals

Hidetoshi Sato, Yusuke Hattori, Yusuke Oshima, Yuichi Komachi, Takashi Katagiri, Toru Asakura, Toru Shimosegawa, Yuji Matsuura, Mitsunobu Miyagi, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, Hideo Tashiro

Author Affiliations +

Proceedings Volume 6091, Optical Biopsy VI; 60910H (2006) https://doi.org/10.1117/12.645842
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Development of the optical biopsy system for experimental small animals is in progress. A prototype of the system which consists of a miniaturized gastro endoscope unit and Raman probes has been completed by now. The system is developed to study a gastric cancer rat model. The endoscope is 2.5 mm in diameter and is equipped an imaging bundle fiber, illumination fibers, a channel and a mechanism to angle the probe head. The head of the Raman probe comes out through the channel and it is possible to aim the probe to the target watching on the monitor. The endoscope was inserted into the anaesthetized healthy rat under the breathing support. It was successfully observed inside of the stomach of the living rat and measured Raman spectra. The spectrum of blood vessels contains the strong contribution from lipids. The present results demonstrate high potential of the system in the in vivo Raman study using the rat model.

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Hidetoshi Sato, Yusuke Hattori, Yusuke Oshima, Yuichi Komachi, Takashi Katagiri, Toru Asakura, Toru Shimosegawa, Yuji Matsuura, Mitsunobu Miyagi, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, and Hideo Tashiro "Development of the optical biopsy system for small experimental animals", Proc. SPIE 6091, Optical Biopsy VI, 60910H (22 February 2006); https://doi.org/10.1117/12.645842

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