Design and fabrication of a disposable percutaneous glucose sensor

Kuo-Chih Liao; Thieo Hogen-Esch; Frances J. Richmond; Laura Marcu; William Clifton; Gerald E. Loeb

doi:10.1117/12.643990

15 February 2006 Design and fabrication of a disposable, percutaneous glucose sensor

Kuo-Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, William Clifton, Gerald E. Loeb

Proceedings Volume 6083, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI; 60830V (2006) https://doi.org/10.1117/12.643990
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Sencils^tm (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophores bound to betacyclodextrin and Concanavalin A (Con A) in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-500mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Citation Download Citation

Kuo-Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, William Clifton, and Gerald E. Loeb "Design and fabrication of a disposable, percutaneous glucose sensor", Proc. SPIE 6083, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI, 60830V (15 February 2006); https://doi.org/10.1117/12.643990

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