Collagenous colitis: new diagnostic possibilities with endomicroscopy

A. Hoffman M.D.; M. Goetz; S. Biesterfeld M.D.; P. R. Galle; M. F. Neurath; R. Kiesslich M.D.

doi:10.1117/12.645054

23 February 2006 Collagenous colitis: new diagnostic possibilities with endomicroscopy

A. Hoffman M.D., M. Goetz, S. Biesterfeld M.D., P. R. Galle, M. F. Neurath, R. Kiesslich M.D.

Proceedings Volume 6082, Endoscopic Microscopy; 608206 (2006) https://doi.org/10.1117/12.645054
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Collagenous colitis is a kind of microscopic colitis. It is characterized by chronic watery diarrhea and abdominal pain. The etiology is still unknown. So far, for the diagnose a histological evaluation was necessary with the presence of thickened subepithelial collagneous bands in the lamina propria. A new developed endoscope with a confocal laser allows analysing cellular and subcellular details of the mucosal layer at high resolution in vivo. In this case report we describe for the first time to diagnose collagenous colitis during ongoing colonoscopy by using this confocal endomicroscopy. In a 67 year old female patient with typical symptoms the characteristic histological changes could be identified in the endomicroscopic view. Biopsies could be targeted to affected areas and endomicroscopic prediction of the presence of collagenous bands could be confirmed in all targeted biopsies. First endomicroscopic experience in microscopic colitis could be confirmed in four additional patients. Future prospective studies are warranted to further evaluate these initial findings. However, collagenous colitis is frequently missed and endomicroscopy seems to be the ideal tool for accurate diagnosing collagenous colitis during ongoing endoscopy.

Citation Download Citation

A. Hoffman M.D., M. Goetz, S. Biesterfeld M.D., P. R. Galle, M. F. Neurath, and R. Kiesslich M.D. "Collagenous colitis: new diagnostic possibilities with endomicroscopy", Proc. SPIE 6082, Endoscopic Microscopy, 608206 (23 February 2006); https://doi.org/10.1117/12.645054

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KEYWORDS

Confocal microscopy

Endomicroscopy

Endoscopy

Biopsy

Diagnostics

Colon

Endoscopes

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