Imaging with a terahertz quantum cascade laser for biomedical applications

Seongsin M. Kim; Fariba Hatami; Allison W. Kurian M.D.; Lynford Goddard; James Ford M.D.; James S. Harris; Giacomo Scalari; Marcella Giovannini; Nicolas Hoyler; Jerome Faist; Geoff Harris

doi:10.1117/12.630999

17 November 2005 Imaging with a terahertz quantum cascade laser for biomedical applications

Seongsin M. Kim, Fariba Hatami, Allison W. Kurian M.D., Lynford Goddard, James Ford M.D., James S. Harris, Giacomo Scalari, Marcella Giovannini, Nicolas Hoyler, Jerome Faist, Geoff Harris

Author Affiliations +

Proceedings Volume 6010, Infrared to Terahertz Technologies for Health and the Environment; 60100I (2005) https://doi.org/10.1117/12.630999
Event: Optics East 2005, 2005, Boston, MA, United States

Abstract

We investigated and demonstrated bio-medical imaging using a THz quantum cascade laser. With the THz quantum cascade laser (QCL) at 3.8 THz, we obtained large dynamic range and high spatial resolution in the transmission imaging technique. The various tissues images, such as lung, liver, and brain sections from the laboratory mouse were obtained and studied. The most important factor for this imaging scheme is to obtain high contrast with different absorption characteristics in tissues. We explored distinct images from the fat, muscles and tendon from the freshly cut tissues and investigated absorption coefficient and compared with FTIR measurement. We also demonstrated the image of distinct region of tumors progressed and normal tissues using this technique. The comparison of frequency dependent medical imaging with utilizing different wavelength of QCLs has been addressed.

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Seongsin M. Kim, Fariba Hatami, Allison W. Kurian M.D., Lynford Goddard, James Ford M.D., James S. Harris, Giacomo Scalari, Marcella Giovannini, Nicolas Hoyler, Jerome Faist, and Geoff Harris "Imaging with a terahertz quantum cascade laser for biomedical applications", Proc. SPIE 6010, Infrared to Terahertz Technologies for Health and the Environment, 60100I (17 November 2005); https://doi.org/10.1117/12.630999

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