Analytical simulation of thermal processes under laser light interaction with multilayered biological tissue

Vladimir V. Barun; Arkady P. Ivanov

doi:10.1117/12.640141

7 December 2006 Analytical simulation of thermal processes under laser light interaction with multilayered biological tissue

Vladimir V. Barun, Arkady P. Ivanov

Author Affiliations +

Proceedings Volume 5973, Current Research on Laser Use in Oncology: 2000-2004; 59730P (2006) https://doi.org/10.1117/12.640141
Event: Current Research on Laser Use in Oncology: 2000-2004, 2004, Moscow, Russian Federation

Abstract

An analytical procedure to study linear thermal processes in multilayered biological tissues irradiated by a laser beam is proposed. The procedure is based on the simplified representation of the heat source function after the irradiation. The Green function of both temporal and radial coordinates of the thermal problem is analytically derived in the paper. It enables one to easy simulate spatial and temporal temperature distributions in tissue by a simple convolution. Pulsed or continuous-wave laser beams with any radial structures can be treated. The validity of the approximations assumed to get the Green function is verified by comparing the simulations with published data on both light and thermal fields in tissues. Rather a good agreement is shown. Specific attention is paid to the most critical approximation, namely to the separation of radial and depth coordinates in the thermal source function. The applicability of such an approach is discussed and quantitatively checked by evaluating the temporal dynamics of radial light and heat spot spreading. The procedure is used to study thermal processes in irradiated skin layers under wide variations of optical parameters of the problem. Sample results on the heating effects of a sensitizer used for photodynamic therapy are illustrated.

Citation Download Citation

Vladimir V. Barun and Arkady P. Ivanov "Analytical simulation of thermal processes under laser light interaction with multilayered biological tissue", Proc. SPIE 5973, Current Research on Laser Use in Oncology: 2000-2004, 59730P (7 December 2006); https://doi.org/10.1117/12.640141

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available