Label-free detection of biomolecules by waveguide interferometry

Katrin Schmitt; Bernd Schirmer; Albrecht Brandenburg

doi:10.1117/12.623711

23 May 2005 Label-free detection of biomolecules by waveguide interferometry

Katrin Schmitt, Bernd Schirmer, Albrecht Brandenburg

Proceedings Volume 5855, 17th International Conference on Optical Fibre Sensors; (2005) https://doi.org/10.1117/12.623711
Event: 17th International Conference on Optical Fibre Sensors, 2005, Bruges, Belgium

Abstract

We report on a recently developed highly sensitive instrument for label-free detection of biomolecules based on the principle of a Young interferometer. With this technology, biomolecular interactions can be detected in real-time without elaborate sample preparation using a planar waveguide as sensing element. The binding reaction of the antibody-antigen pair immunoglobulin G and protein G has been studied and an affinity constant of K=2.6*10⁷ M^-1 has been determined.

Citation Download Citation

Katrin Schmitt, Bernd Schirmer, and Albrecht Brandenburg "Label-free detection of biomolecules by waveguide interferometry", Proc. SPIE 5855, 17th International Conference on Optical Fibre Sensors, (23 May 2005); https://doi.org/10.1117/12.623711

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