Interfacing peptides identified using phage-display screening with quantum dots for the design of nanoprobes

Sawitri Mardyani; Anupam Singhal; Wen Jiang; Warren C. W. Chan

doi:10.1117/12.601609

28 April 2005 Interfacing peptides identified using phage-display screening with quantum dots for the design of nanoprobes

Sawitri Mardyani, Anupam Singhal, Wen Jiang, Warren C. W. Chan

Author Affiliations +

Proceedings Volume 5705, Nanobiophotonics and Biomedical Applications II; (2005) https://doi.org/10.1117/12.601609
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).

Citation Download Citation

Sawitri Mardyani, Anupam Singhal, Wen Jiang, and Warren C. W. Chan "Interfacing peptides identified using phage-display screening with quantum dots for the design of nanoprobes", Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); https://doi.org/10.1117/12.601609

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