Gold nanoparticles: a novel application of spectral imaging in proteomics - preliminary results

Heidelinde Regina Christina Dietrich; Ian Ted Young; Yuval Garini

doi:10.1117/12.587517

23 March 2005 Gold nanoparticles: a novel application of spectral imaging in proteomics -- preliminary results

Heidelinde Regina Christina Dietrich, Ian Ted Young, Yuval Garini

Proceedings Volume 5694, Spectral Imaging: Instrumentation, Applications, and Analysis III; (2005) https://doi.org/10.1117/12.587517
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

The intense research in proteomics is demanding for fast, reliable and easy-to-use methods in order to study the proteome. In this proceeding we report the development of such a novel research tool based on spectral imaging and Resonance Light Scattering gold particles. This method will allow the study of DNA-protein interactions. We suggest a broad range of applications: the screening of proteins binding to a specific DNA sequence, the analysis of binding affinities between protein and DNA, and the investigation of the influence of environmental conditions on the binding. We will explain the principle, first experiments and first results based on Brownian motion.

Citation Download Citation

Heidelinde Regina Christina Dietrich, Ian Ted Young, and Yuval Garini "Gold nanoparticles: a novel application of spectral imaging in proteomics -- preliminary results", Proc. SPIE 5694, Spectral Imaging: Instrumentation, Applications, and Analysis III, (23 March 2005); https://doi.org/10.1117/12.587517

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