High-resolution second harmonic optical coherence tomography

Yi Jiang; Ivan V. Tomov; Yimin Wang; Zhongping Chen

doi:10.1117/12.591879

13 April 2005 High-resolution second harmonic optical coherence tomography

Yi Jiang, Ivan V. Tomov, Yimin Wang, Zhongping Chen

Proceedings Volume 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX; (2005) https://doi.org/10.1117/12.591879
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

A high-resolution Second Harmonic Optical Coherence Tomography (SH-OCT) system is demonstrated using a spectrum broadened femtosecond Ti:sapphire laser. An axial resolution of 4.2 μm at the second harmonic wave center wavelength of 400 nm has been achieved. Because the SH-OCT system uses the second harmonic generation signals that strongly depend on the orientation, polarization and local symmetry properties of chiral molecules, this technique provides unique contrast enhancement to conventional optical coherence tomography. The system is applied to image biological tissues like the rat-tail tendon. Images of highly organized collagen fibrils in the rat-tail tendon have been demonstrated.

Citation Download Citation

Yi Jiang, Ivan V. Tomov, Yimin Wang, and Zhongping Chen "High-resolution second harmonic optical coherence tomography", Proc. SPIE 5690, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, (13 April 2005); https://doi.org/10.1117/12.591879

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