Discrimination of atherosclerotic plaque constituents based on local measurements of optical attenuation coefficents by OCT

Freek J. van der Meer; Jop Perree; Dirk J. Faber; David M. Baraznji Sassoon; Maurice C. G. Aalders; Ton G. van Leeuwen

doi:10.1117/12.592357

25 April 2005 Discrimination of atherosclerotic plaque constituents based on local measurements of optical attenuation coefficents by OCT

Freek J. van der Meer, Jop Perree, Dirk J. Faber, David M. Baraznji Sassoon, Maurice C. G. Aalders, Ton G. van Leeuwen

Author Affiliations +

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.592357
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Imaging of human autopsy samples was performed from the luminal side with a high (3.5 μm axial and 7 μm lateral) resolution OCT system (around 800 nm) or a regular (15-20 μm axial and 20 μm lateral resolution) OCT system (around 1300 nm). For each sample, dimensions were measured by histomorphometry and OCT and the optical attenuation was measured. Quantitative analysis showed a strong and significant correlation between OCT and histology cap thickness measurements for both OCT systems. For both systems, the measured attenuation coefficients of diffuse intimal thickening and lipid-rich regions differed significantly from media and calcifications. Both the high and regular resolution OCT systems can precisely image the atherosclerotic plaques. Quantitative analysis of the OCT signals allowed in situ determination of the intrinsic optical attenuation coefficient of atherosclerotic tissue components within regions of interest, which can further help to discriminate the plaque and arterial wall components.

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Freek J. van der Meer, Jop Perree, Dirk J. Faber, David M. Baraznji Sassoon, Maurice C. G. Aalders, and Ton G. van Leeuwen "Discrimination of atherosclerotic plaque constituents based on local measurements of optical attenuation coefficents by OCT", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.592357

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