Analysis of time evolution of fluorescence and absorption spectra of camptothecins

Blanka Ziomkowska; Stefan Kruszewski; Ryszard Siuda; Michal Cyrankiewicz

doi:10.1117/12.577162

26 August 2004 Analysis of time evolution of fluorescence and absorption spectra of camptothecins

Blanka Ziomkowska, Stefan Kruszewski, Ryszard Siuda, Michal Cyrankiewicz

Proceedings Volume 5566, Optical Security and Safety; (2004) https://doi.org/10.1117/12.577162
Event: Optical Security and Safety, 2003, Warsaw, Poland

Abstract

Camptothecins, fluorescent anticancer agents, exhibit at neutral and physiological pH changes over time in absorption and fluorescence spectra. Analysis of these changes is a subject of this paper. Factor analysis of fluorescence spectra enabled to determine the kinetics of hydrolysis of camptothecin, i.e. the rate of converting of biologically active lactone form into inactive carboxylate. Obtained results are compared with HPLC data.

Citation Download Citation

Blanka Ziomkowska, Stefan Kruszewski, Ryszard Siuda, and Michal Cyrankiewicz "Analysis of time evolution of fluorescence and absorption spectra of camptothecins", Proc. SPIE 5566, Optical Security and Safety, (26 August 2004); https://doi.org/10.1117/12.577162

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