A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner

Steven M. Jorgensen; Michael S. Chmelik; Diane R. Eaker; Carolyn A. MacDonald; Erik Leo Ritman M.D.

doi:10.1117/12.560991

26 October 2004 A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner

Steven M. Jorgensen, Michael S. Chmelik, Diane R. Eaker, Carolyn A. MacDonald, Erik Leo Ritman M.D.

Proceedings Volume 5535, Developments in X-Ray Tomography IV; (2004) https://doi.org/10.1117/12.560991
Event: Optical Science and Technology, the SPIE 49th Annual Meeting, 2004, Denver, Colorado, United States

Abstract

To show the feasibility of a combined micro-CT and micro-SPECT scanner based on use of polycapillary optics we inserted an optic between the radio-labeled specimen and our micro-CT scanner's imaging system. The micro-CT x-ray focal spot was placed at the focal point of the optic so that x-ray micro-CT of the specimen could also be performed without having to move the specimen. Using this set-up we scanned a 2 cm diameter Plexiglas cylinder with three (177 μCi) prostate brachytherapy seeds embedded in it. Each seed was 0.5 mm diameter, 4 mm long and filled with 0.4 mm diameter ceramic beads coated with ¹²⁵Iodine. The SPECT images clearly resolve the layer of ¹²⁵Iodine on the beads. That the SPECT image is spatially correct was cofirmed by the concurrent CT image. We also used a parallel polycapillary optic to scan a 1.5 cm Plexiglas cylinder with holes (2, 1, and 0.5 mm diameter, parallel to the cylinder axis) filled with a solution containing 11.56μCi/mm³ of ¹²⁵Iodine. These data indicate a spatial resolution of 5 line pairs per mm at 10% modulation. Based on these results we propose a design that is more efficient at acquiring the scintigraphic image data.

Citation Download Citation

Steven M. Jorgensen, Michael S. Chmelik, Diane R. Eaker, Carolyn A. MacDonald, and Erik Leo Ritman M.D. "A polycapillary x-ray optics-based integrated micro-SPECT/CT scanner", Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); https://doi.org/10.1117/12.560991

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