In vitro osteosarcoma biosensing using THz time domain spectroscopy

Bradley S. Ferguson; Haibo Liu; Shelley Hay; David Findlay; Xi-Cheng Zhang; Derek Abbott

doi:10.1117/12.527880

29 March 2004 In vitro osteosarcoma biosensing using THz time domain spectroscopy

Bradley S. Ferguson, Haibo Liu, Shelley Hay, David Findlay, Xi-Cheng Zhang, Derek Abbott

Proceedings Volume 5275, BioMEMS and Nanotechnology; (2004) https://doi.org/10.1117/12.527880
Event: Microelectronics, MEMS, and Nanotechnology, 2003, Perth, Australia

Abstract

Terahertz time domain spectroscopy (THz-TDS) has a wide range of applications from semiconductor diagnostics to biosensing. Recent attention has focused on bio-applications and several groups have noted the ability of THz-TDS to differentiate basal cell carcinoma tissue from healthy dermal tissue ex vivo. The contrast mechanism is unclear but has been attributed to increased interstitial water in cancerous tissue. In this work we investigate the THz response of human osteosarcoma cells and normal human bone cells grown in culture to isolate the cells' responses from other effects. A classification algorithms based on a frequency selection by genetic algorithm is used to attempt to differentiate between the cell types based on the THz spectra. Encouraging preliminary results have been obtained.

Citation Download Citation

Bradley S. Ferguson, Haibo Liu, Shelley Hay, David Findlay, Xi-Cheng Zhang, and Derek Abbott "In vitro osteosarcoma biosensing using THz time domain spectroscopy", Proc. SPIE 5275, BioMEMS and Nanotechnology, (29 March 2004); https://doi.org/10.1117/12.527880

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available