Physics of drug delivery: dielectric spectroscopy to probe mucoadhesion

Maria Stromme

doi:10.1117/12.497685

29 April 2003 Physics of drug delivery: dielectric spectroscopy to probe mucoadhesion

Maria Stromme

Proceedings Volume 5118, Nanotechnology; (2003) https://doi.org/10.1117/12.497685
Event: Microtechnologies for the New Millennium 2003, 2003, Maspalomas, Gran Canaria, Canary Islands, Spain

Abstract

This work presents how dielectric spectroscopy can be used as a tool to obtain insight about properties on the nano-scale of interfaces of pharmaceutical interest. An outline for studying the adhesion in terms of a compatibility factor between pharmaceutical gels and biological tissue is put forward. The proposed compatibility factor is calculated from the high frequency response (kHz region) of the gel and porcine nasal mucosa separately, and from that of the combined system. It gives an assessment of the possibilities of intimate surface contact, which is generally considered to be the first step in the mucoadhesion process. The results from dielectric spectroscopy were compared to measurements using a tensile strength method and it was found that the gels with the highest compatibility factors were the same as those pointed out as having the highest mucoadhesion using the tensile strength method.

Citation Download Citation

Maria Stromme "Physics of drug delivery: dielectric spectroscopy to probe mucoadhesion", Proc. SPIE 5118, Nanotechnology, (29 April 2003); https://doi.org/10.1117/12.497685

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available