Design and characterization of a large-area lens-coupled CCD detector for macromolecular crystallography

Edwin M. Westbrook; John Morse; Robert E. Fischer; William M. McGuigan; Steven K. Onishi; Paul Vu; Istvan Naday; C. Bauer; J. Phillips; T. A. Thorson; Roger D. Durst

doi:10.1117/12.451165

10 January 2003 Design and characterization of a large-area lens-coupled CCD detector for macromolecular crystallography

Edwin M. Westbrook, John Morse, Robert E. Fischer, William M. McGuigan, Steven K. Onishi, Paul Vu, Istvan Naday, C. Bauer, J. Phillips, T. A. Thorson, Roger D. Durst

Author Affiliations +

Proceedings Volume 4784, X-Ray and Gamma-Ray Detectors and Applications IV; (2003) https://doi.org/10.1117/12.451165
Event: International Symposium on Optical Science and Technology, 2002, Seattle, WA, United States

Abstract

We have prototyped and characterized a very large format X-ray detector for macromolecular crystallography. The X-ray field strength is converted to visible light in a phosphor film. Light from the phosphor is focused onto a CCD imager by a lens specially designed for this detector, that has a very high numerical aperture. The CCD is very large (61 mm, 4,096 × 4,096 pixels), and employs a very low-noise on-chip preamplifier. Lens coupling between phosphor film and CCD avoids many of the optical imperfections of fiber optic coupling, but it remains a challenge to make a lens system with optical transfer efficiency matching or exceeding that of fiber optical systems. We have met this challenge by enhancing system gain in our detector through implementation of modern lens technologies and imaginative CCD design. At this point the system gain equals that of conventional CCD-based X-ray crystallography detectors, which couple the CCD to the phosphor through a fiber optic taper. Although many of our technical developments could also be used in fiber optic detectors, the overriding virtues of the lens-couple detector are simplicity, optical perfection, and cost.

Citation Download Citation

Edwin M. Westbrook, John Morse, Robert E. Fischer, William M. McGuigan, Steven K. Onishi, Paul Vu, Istvan Naday, C. Bauer, J. Phillips, T. A. Thorson, and Roger D. Durst "Design and characterization of a large-area lens-coupled CCD detector for macromolecular crystallography", Proc. SPIE 4784, X-Ray and Gamma-Ray Detectors and Applications IV, (10 January 2003); https://doi.org/10.1117/12.451165

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available