Imaging of drug effects in perfused liver

Marc Dammann; Christine Mahlke; Manfred D. Kessler

doi:10.1117/12.469470

5 June 2002 Imaging of drug effects in perfused liver

Marc Dammann, Christine Mahlke, Manfred D. Kessler

Proceedings Volume 4623, Functional Monitoring and Drug-Tissue Interaction; (2002) https://doi.org/10.1117/12.469470
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Various medications affect the systemic circulation and organ oxygenation causing dilatation or constriction of blood vessels. Imminent liver failure can be generated by reduced perfusion of different origins. In this case hepatic vasodilatation would be a therapeutical approach for improving patient's condition. Our examinations have been performed in perfused rat liver using spectrometric methods. Two defined areas of the liver were measured punctually. We compared the influence of Tetramethylpyrazine and Glyceroltrinitrate on hemoglobin oxygenation (HbO2) and concentration (Hb-conc.) in rat liver after application of Norepinephrine, which caused a mid decrease in hemoglobin oxygenation of 47,9 %. Both increased the HbO₂, but differed from each other in manner of time and extent. Tetramethylpyrazine indicated a longer effect than Glyceroltrinitrate. Furthermore, HbO₂ and Hb-conc. showed a conversed relation. From the shape of the absorption spectra it is possible to derive the oxygenation of hemoglobin.

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Marc Dammann, Christine Mahlke, and Manfred D. Kessler "Imaging of drug effects in perfused liver", Proc. SPIE 4623, Functional Monitoring and Drug-Tissue Interaction, (5 June 2002); https://doi.org/10.1117/12.469470

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KEYWORDS

Liver

Veins

Absorption

Optical fibers

Oxygen

Capillaries

Spectroscopy

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