Solid state lasers for photodynamic therapy of malignant neoplasm

Vitaliy M. Khulugurov; Nikolai Ivanov; Byoung-Chul Kim; Alexander Mayorov; Dnitri Bordzilovsky; Valentina Masycheva; Elena Danilenko; Moon-Kwan Chung

doi:10.1117/12.466650

13 May 2002 Solid state lasers for photodynamic therapy of malignant neoplasm

Vitaliy M. Khulugurov, Nikolai Ivanov, Byoung-Chul Kim, Alexander Mayorov, Dnitri Bordzilovsky, Valentina Masycheva, Elena Danilenko, Moon-Kwan Chung

Author Affiliations +

Proceedings Volume 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV; (2002) https://doi.org/10.1117/12.466650
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

This work demonstrates the possibility of treating animals with malignant neoplasms using 608 nm of laser radiation by means of photodynamic therapy (PDT). The intracavity transformation of the Nd:YAP main radiation 1079 nm was Raman converted in barium nitrate crystal, and the Stokes frequency (1216 nm) was doubled using KTP or RTA crystals. The LiF or Cr:YAG crystals are used for the Q-switch. The radiation parameters were obtained at 100 Hz pump repetition frequency. The average power at 608-nm radiation with LiF and KTP was 700 mW at multimode generation. The 3-6 single 10-15 ns pulses were generated during one cycle of pumping. The doubling efficiency with RTA was two times more than with KTP. The cells of Ehrlich adenocarcinoma (0.1 ml) were implanted in hind thighs of ICR white non-imbred mice. Photosensitizer HpD was i.v. administered in a dose of 10 mg/kg. Ten animals were treated (2 as a control). There was a 9-30% decrease in the tumor growth depending on the irradiation dose. The better result (30%) was for the 200 J/cm² dose radiation. These results show the possibility of using all solid state lasers with wavelength of 608 nm for PDT.

Citation Download Citation

Vitaliy M. Khulugurov, Nikolai Ivanov, Byoung-Chul Kim, Alexander Mayorov, Dnitri Bordzilovsky, Valentina Masycheva, Elena Danilenko, and Moon-Kwan Chung "Solid state lasers for photodynamic therapy of malignant neoplasm", Proc. SPIE 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, (13 May 2002); https://doi.org/10.1117/12.466650

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available