Insect-gene-activity detection system for chemical and biological warfare agents and toxic industrial chemicals

Ryan S. Mackie; Amanda S. Schilling; Arturo M. Lopez; Alfredo Rayms-Keller

doi:10.1117/12.456912

21 February 2002 Insect-gene-activity detection system for chemical and biological warfare agents and toxic industrial chemicals

Ryan S. Mackie, Amanda S. Schilling, Arturo M. Lopez, Alfredo Rayms-Keller

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Proceedings Volume 4575, Chemical and Biological Early Warning Monitoring for Water, Food, and Ground; (2002) https://doi.org/10.1117/12.456912
Event: Environmental and Industrial Sensing, 2001, Boston, MA, United States

Abstract

Detection of multiple chemical and biological weapons (CBW) agents and/or complex mixtures of toxic industrial chemicals (TIC) is imperative for both the commercial and military sectors. In a military scenario, a multi-CBW attack would create confusion, thereby delaying decontamination and therapeutic efforts. In the commercial sector, polluted sites invariably contain a mixture of TIC. Novel detection systems capable of detecting CBW and TIC are sorely needed. While it may be impossible to build a detector capable of discriminating all the possible combinations of CBW, a detection system capable of statistically predicting the most likely composition of a given mixture is within the reach of current emerging technologies. Aquatic insect-gene activity may prove to be a sensitive, discriminating, and elegant paradigm for the detection of CBW and TIC. We propose to systematically establish the expression patterns of selected protein markers in insects exposed to specific mixtures of chemical and biological warfare agents to generate a library of biosignatures of exposure. The predicting capabilities of an operational library of biosignatures of exposures will allow the detection of emerging novel or genetically engineered agents, as well as complex mixtures of chemical and biological weapons agents. CBW and TIC are discussed in the context of war, terrorism, and pollution.

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Ryan S. Mackie, Amanda S. Schilling, Arturo M. Lopez, and Alfredo Rayms-Keller "Insect-gene-activity detection system for chemical and biological warfare agents and toxic industrial chemicals", Proc. SPIE 4575, Chemical and Biological Early Warning Monitoring for Water, Food, and Ground, (21 February 2002); https://doi.org/10.1117/12.456912

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KEYWORDS

Metals

Proteins

Biological weapons

Industrial chemicals

Toxic industrial chemicals

Biological detection systems

Organisms

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