Optical detection of (pre-)malignant lesions of the oral mucosa: autofluorescence characteristics of healthy mucosa

Diana C. G. de Veld; Max Witjes; Jan L.N. Roodenburg; Willem M. Star; Hericus J. C. M. Sterenborg

doi:10.1117/12.447135

31 October 2001 Optical detection of (pre-)malignant lesions of the oral mucosa: autofluorescence characteristics of healthy mucosa

Diana C. G. de Veld, Max Witjes, Jan L.N. Roodenburg, Willem M. Star, Hericus J. C. M. Sterenborg

Author Affiliations +

Proceedings Volume 4432, Diagnostic Optical Spectroscopy in Biomedicine; (2001) https://doi.org/10.1117/12.447135
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

Previous clinical results demonstrate the potential of in vivo autofluorescence spectroscopy for early detection of (pre-)malignant lesions of the oral mucosa. For reliable diagnosis, it is necessary to study autofluorescence spectra of healthy mucosa first. We measured excitation-emission maps in healthy subjects and subjects with a history of cancer in the head -neck region. Our results show that different anatomical locations produce distinct autofluorescence spectra. Influences of, among others, smoking and drinking habits require further investigation.

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Diana C. G. de Veld, Max Witjes, Jan L.N. Roodenburg, Willem M. Star, and Hericus J. C. M. Sterenborg "Optical detection of (pre-)malignant lesions of the oral mucosa: autofluorescence characteristics of healthy mucosa", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447135

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