Parallel confocal systems for biomedical application

Rong Yang; Qingsheng He; Minxian Wu; Yingbai Yan; Guofan Jin

doi:10.1117/12.438191

22 August 2001 Parallel confocal systems for biomedical application

Rong Yang, Qingsheng He, Minxian Wu, Yingbai Yan, Guofan Jin

Proceedings Volume 4378, Chemical and Biological Sensing II; (2001) https://doi.org/10.1117/12.438191
Event: Aerospace/Defense Sensing, Simulation, and Controls, 2001, Orlando, FL, United States

Abstract

A parallel confocal method including an optical diffractive element, a Dammann grating, is presented. Dammann gratings manufactured with microfabrication technologies have the ability to generate several beams with identical intensity. An optical confocal system combining with a Dammann grating will form multi-channel confocal optical structures, so that it can achieve a planar image instantly without scanning. This parallel confocal fluorescence detection system has the merits of discarding scanning part, compact structure, real time imaging and detection and high S/N ratio, therefore it is suitable for detection of dye-labelled DNA array chips and for other biomedical applications. Structural considerations and design of a parallel confocal fluorescence setup and experimental results of detecting a dye-labeled DNA array chip are presented in this paper.

Citation Download Citation

Rong Yang, Qingsheng He, Minxian Wu, Yingbai Yan, and Guofan Jin "Parallel confocal systems for biomedical application", Proc. SPIE 4378, Chemical and Biological Sensing II, (22 August 2001); https://doi.org/10.1117/12.438191

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KEYWORDS

Confocal microscopy

Point spread functions

Diffraction gratings

Fluorescence spectroscopy

Biomedical optics

Luminescence

Signal detection

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