Comparison of competing fiber optic probes for tissue fluorescence analysis

Nikolay A. Denisov

doi:10.1117/12.409334

16 November 2000 Comparison of competing fiber optic probes for tissue fluorescence analysis

Nikolay A. Denisov

Proceedings Volume 4161, Optical Biopsy and Tissue Optics; (2000) https://doi.org/10.1117/12.409334
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

Several fiber optic probes attached single- or multi-fiber light delivery systems have been competitively examined for purposes of in vivo tissue fluorescence spectroscopy with endoscopic technique use. The effects of the probes' designs and excitation/receiving fiber geometry on fluorescence spectra are analyzed with the sensor optical efficiency (SOE) coefficient and the tip coupling efficiency (TCE) one calculated by means of ray tracing. The profiles of the excitation beam as well as fluorescence profiles were simulated with uniform and Gaussian cross power distributions, whereas the diameter of the tissue surface area from which fluorescence light was collected was taken as five diameter of the tissue surface area directly illuminated by the excitation beam. The plots of the SOE-coefficients versus changeable probe-tissue gap simulated possible peristaltic tissue movement during clinical in situ spectroscopic optical biopsy would be a helpful tool for specialists to design novel endoscopic fiber optic catheters to differentiate normal and pathologic tissues.

Citation Download Citation

Nikolay A. Denisov "Comparison of competing fiber optic probes for tissue fluorescence analysis", Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); https://doi.org/10.1117/12.409334

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