In-plane scatterometry of small caliber blood column

Arthur Lompado; Matthew H. Smith; Lloyd W. Hillman; Kurt R. Denninghoff

doi:10.1117/12.387144

31 May 2000 In-plane scatterometry of small caliber blood column

Arthur Lompado, Matthew H. Smith, Lloyd W. Hillman, Kurt R. Denninghoff

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387144
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The scattering of He-Ne laser light incident on a flowing column of whole human blood has been measured and analyzed. An automated scatterometer whose sample chamber simulates a small caliber blood vessel was used to perform the measurements and is described. Angular scattered light distributions due to flowing blood columns for two independently varied parameters, blood oxygenation and hemoglobin concentration, are presented. It is found that the dependence of the scattering distribution on blood oxygenation is minimal while the dependence on hemoglobin concentration is strong. A nominally transparent sample of human plasma has also been investigated to quantify its scattering characteristics. The whole blood scattering results are compared to theoretical predictions obtained using a Monte Carlo simulation employing the Mie single particle phase function and macroscopic transport coefficients obtained from published literature. The best correlation was found when the largest published scattering coefficient was employed in the simulation. However, a strong correlation between the measured and predicted scattering distributions was only obtained when unphysically high values of the scattering coefficient were used in the simulation.

Citation Download Citation

Arthur Lompado, Matthew H. Smith, Lloyd W. Hillman, and Kurt R. Denninghoff "In-plane scatterometry of small caliber blood column", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387144

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