Refractive index of biotissue and its thermal response

Hui Li; Shusen Xie; Lei Lin

doi:10.1117/12.388072

13 June 2000 Refractive index of biotissue and its thermal response

Hui Li, Shusen Xie, Lei Lin

Proceedings Volume 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical; (2000) https://doi.org/10.1117/12.388072
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The main significance about the refractive index of bio- tissue, its measurement methods and its thermal properties in particular are presented in this paper. Most of bio-tissue can be regarded as random dispersed medium which inhomogeneous dimension is about the order of micrometers. In order to describe the optical behaviors of bio-tissue, we have to use the imaginary scattering and absorption properties. Meanwhile, an apparent index of refraction, or average refractive index has to be introduced to solve various boundary and temporal problems. Two possible measurement methods in which the experimental creativity is reflected are provided. We applied one of experimental setups to study the thermal response of refractive index of bio-tissue. Experimental results suggest that the index be temperature dependent on the process of heating. The tissues used in these experiments were porcine muscles. These measurements were taken at the 632.8 nm. The index of refraction keeps stable levels (1.364 +/- 0.001) below 36 Celsius degrees and (1.387 +/- 0.005) above 60 Celsius degrees, respectively, but increases with an increase in temperature from 36 to 60 Celsius degrees. The heating and cooling procedures are irreversible in optical property of tissue.

Citation Download Citation

Hui Li, Shusen Xie, and Lei Lin "Refractive index of biotissue and its thermal response", Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); https://doi.org/10.1117/12.388072

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