Endogenous CO monitoring in exhalation with tunable diode lasers: applications to clinical and biomedical diagnostics

Eugene V. Stepanov; Pavel V. Zyrianov; Valerii A. Miliaev; Yurii A. Shulagin; Alexander I. D'yachenko

doi:10.1117/12.353110

14 July 1999 Endogenous CO monitoring in exhalation with tunable diode lasers: applications to clinical and biomedical diagnostics

Eugene V. Stepanov, Pavel V. Zyrianov, Valerii A. Miliaev, Yurii A. Shulagin, Alexander I. D'yachenko

Author Affiliations +

Proceedings Volume 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology; (1999) https://doi.org/10.1117/12.353110
Event: Selected Papers from Seventh International Conference on Advanced Laser Technologies (ALT'98): Laser Methods in Medicine and Biology, 1998, Tallin, Estonia

Abstract

Middle IR tunable diode lasers were applied to studies of pulmonary excretion of endogenous carbon monoxide (CO). Variations of the CO content level in exhaled air of healthy nonsmokers were investigated for different environmental conditions with the applied laser technique. Correlation of the obtained data with atmospheric CO contamination and elevated oxygen content were studied as well as diurnal variations of the endogenous CO in exhalation was observed. Criteria for correct conditions of the endogenous CO detection in breath could be derive don this basis. Developed laser approach and methods were applied for the analysis of the excreted CO level in different diseases like bronchial asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, anemia and hepatitis. Laser based close-to-real-time monitoring of the endogenous CO elimination with breath in the course of different dynamic tests was demonstrated to be informative in studies of blood oxygen transport and pH variations in tissues for different challenges tests in human physiology.

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Eugene V. Stepanov, Pavel V. Zyrianov, Valerii A. Miliaev, Yurii A. Shulagin, and Alexander I. D'yachenko "Endogenous CO monitoring in exhalation with tunable diode lasers: applications to clinical and biomedical diagnostics", Proc. SPIE 3829, ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology, (14 July 1999); https://doi.org/10.1117/12.353110

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