Use of entangled-photon imaging in optical biopsy: a feasibility study

Ervin Goldfain

doi:10.1117/12.354947

19 July 1999 Use of entangled-photon imaging in optical biopsy: a feasibility study

Ervin Goldfain

Proceedings Volume 3749, 18th Congress of the International Commission for Optics; (1999) https://doi.org/10.1117/12.354947
Event: ICO XVIII 18th Congress of the International Commission for Optics, 1999, San Francisco, CA, United States

Abstract

We examine a novel diagnostic method suitable for optical biopsy, i.e., the noninvasive in vivo detection of malignant lesions in human tissue. Entangled-photon imaging is an emerging technology based upon the use of non-classical sources of light such as optical parametric oscillators (OPO). These sources generate above-threshold signal and idler beams that have intensity fluctuations highly correlated in space and time (twin beams). It has been shown that low-intensity OPO's make possible high sensitivity absorption measurements of weak targets, below the shot- noise limit. The direct use of this technology for optical biopsy is severely restricted by the large amount of scattering noise associated with light-tissue interaction. We report what is, to our knowledge, the first feasibility study on a differential wavelength, OPO-based setup targeted for mammography. Constraints related to the entanglement time, OPO selection and background suppression are analyzed. The paper concludes with a review of future developments and challenges.

Citation Download Citation

Ervin Goldfain "Use of entangled-photon imaging in optical biopsy: a feasibility study", Proc. SPIE 3749, 18th Congress of the International Commission for Optics, (19 July 1999); https://doi.org/10.1117/12.354947

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