Comparison of contrast medium injection protocols in dynamic hepatic CT: simulation of lesion-to-liver contrast difference using pharmacokinetic compartment modeling

Soo Jeong Kim; K. H. Lee; Jung-Hoon Kim; J. K. Han; Byong Goo Min

doi:10.1117/12.349619

20 May 1999 Comparison of contrast medium injection protocols in dynamic hepatic CT: simulation of lesion-to-liver contrast difference using pharmacokinetic compartment modeling

Soo Jeong Kim, K. H. Lee, Jung-Hoon Kim, J. K. Han, Byong Goo Min

Author Affiliations +

Proceedings Volume 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images; (1999) https://doi.org/10.1117/12.349619
Event: Medical Imaging '99, 1999, San Diego, CA, United States

Abstract

Contrast-enhanced CT has an important role in assessing liver lesions. However, the optimal protocol to get most effective result is not clear. The main goal when deciding injection protocol is to optimize lesion detectability with rapid scanning when lesion-to-liver contrast is maximum. For this purpose, we developed a physiological model of the contrast medium enhancement based on the compartment modeling and pharmacokinetics. Blood supply to liver is achieved in two paths. This dual supply characteristic distinguishes the CT enhancement of liver from that of the other organs. The first path is by hepatic artery and the second, by portal vein. However, it is assumed that only hepatic artery can supply blood to hepatocellular carcinoma (HCC) compartment, thus, the difference of contrast enhancement is resulted between normal liver tissue and hepatic tumor. By solving differential equations for each compartment simultaneously using the computer program Matlab, CT contrast-enhancement curves were simulated. The simulated enhancement curves for aortic, hepatic, portal vein, and HCC compartments were compared with the mean enhancement curves from 24 patients exposed to the same protocols as the simulation. These enhancement curves showed a good agreement. Furthermore, we simulated lesion-to- liver curves for various injection protocols, and the effects were analyzed. The variables to be considered in the injection protocol were injection rate, dose, and concentration of contrast material. These data may help to optimize scanning protocols for better diagnosis.

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Soo Jeong Kim, K. H. Lee, Jung-Hoon Kim, J. K. Han, and Byong Goo Min "Comparison of contrast medium injection protocols in dynamic hepatic CT: simulation of lesion-to-liver contrast difference using pharmacokinetic compartment modeling", Proc. SPIE 3660, Medical Imaging 1999: Physiology and Function from Multidimensional Images, (20 May 1999); https://doi.org/10.1117/12.349619

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KEYWORDS

Liver

Tumor growth modeling

Tumors

Blood

Computed tomography

Veins

Signal attenuation

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