Assessment of glucose content in diabetic patients by examining the core of hair

Narahari V. Joshi; Virgina Otero de Joshi; M. Quintero; A. Osuna

doi:10.1117/12.351537

9 July 1999 Assessment of glucose content in diabetic patients by examining the core of hair

Narahari V. Joshi, Virgina Otero de Joshi, M. Quintero, A. Osuna

Proceedings Volume 3595, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems; (1999) https://doi.org/10.1117/12.351537
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Glucose is known to be an optically active material and therefore in cross polarized light, a bright color will be visualized against a dark background. In non enzymatic glycation glucose is attached to (epsilon) -NH₂ group of Lysine residues of proteins and therefore an irreversible alteration takes place. Glucose molecules along with proteins are deposited in the core of the hair in the growth process and when it is examined under cross polarized radiation bright colored patches, depending upon the thickness of glucose conglomerate, are expected. With this view, we have examined 25 diabetic patients and we have observed the presence of such patches. In controlled cases, these patches were absent provided that the hairs had not received any chemical or heat treatment. If properly exploited, this could be a very useful non-invasive diagnostic tool or guidance for diabetes related phenomena. Moreover, the proteins deposited in the hair core are not altered and are preserved for a long period and hence, it could reveal the history of the patient in relation with his glucose metabolism.

Citation Download Citation

Narahari V. Joshi, Virgina Otero de Joshi, M. Quintero, and A. Osuna "Assessment of glucose content in diabetic patients by examining the core of hair", Proc. SPIE 3595, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems, (9 July 1999); https://doi.org/10.1117/12.351537

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KEYWORDS

Glucose

Proteins

Polarization

Optical activity

Active optics

Molecules

Blood

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