Clinical applications of frequency-domain optical mammography

Sergio Fantini; Oliver Schuetz; Julian Edler; Sylvia Heywang-Koebrunner; Linda Goetz; Maria-Angela Franceschini; Horst Siebold

doi:10.1117/12.334368

30 December 1998 Clinical applications of frequency-domain optical mammography

Sergio Fantini, Oliver Schuetz, Julian Edler, Sylvia Heywang-Koebrunner, Linda Goetz, Maria-Angela Franceschini, Horst Siebold

Author Affiliations +

Proceedings Volume 3566, Photon Propagation in Tissues IV; (1998) https://doi.org/10.1117/12.334368
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

We present clinical results obtained with a frequency-domain (70 MHz), four-wavelength (690, 750, 788, 856 nm) prototype for optical mammography. The 2D projection images are taken on the slightly compressed breast in craniocaudal and oblique projections, similar to what is done in x-ray mammography. The amplitude and phase images are combined to enhance the contrast and the tumor detectability by reducing the edge effects caused by the breast thickness variations within the scanned area. The analysis of the first set of clinical data (63 patients) has yielded encouraging results. The success rate in the detection of breast cancer was 73%, and specificity was 49%. A comparison of the optical mammograms at the four wavelengths in the range 690 - 856 nm suggests that spectral information may allow for the discrimination of benign and malignant breast lesions, thereby enhancing specificity.

Citation Download Citation

Sergio Fantini, Oliver Schuetz, Julian Edler, Sylvia Heywang-Koebrunner, Linda Goetz, Maria-Angela Franceschini, and Horst Siebold "Clinical applications of frequency-domain optical mammography", Proc. SPIE 3566, Photon Propagation in Tissues IV, (30 December 1998); https://doi.org/10.1117/12.334368

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