Interest of ICG blood clearance monitoring for reproducible 810-nm diode laser coagulation of blood vessels

Thomas Desmettre; Sylvie Soulie-Begu; Jean-Marie Devoisselle; Serge R. Mordon

doi:10.1117/12.339168

4 February 1999 Interest of ICG blood clearance monitoring for reproducible 810-nm diode laser coagulation of blood vessels

Thomas Desmettre, Sylvie Soulie-Begu, Jean-Marie Devoisselle, Serge R. Mordon

Author Affiliations +

Proceedings Volume 3564, Medical Applications of Lasers in Dermatology, Cardiology, Ophthalmology, and Dentistry II; (1999) https://doi.org/10.1117/12.339168
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

Purpose: To evaluate a method of control of diode laser fluence leading to a reproducible ICG-enhanced selective photocoagulation of blood vessels. This method would use the chromophore clearance, i.e. ICG blood concentration decay to adapt the laser fluence. Materials and Methods: A skin flap window was used on hamsters. After a 15 mg/kg ICG solution injection, photocoagulation of vessels were performed. Results: Selective photocoagulation of blood vessels was obtained only during the first 10 minutes. The fluence required to obtain a selective photocoagulation of vessels (F) was modelized using a one compartment phamacokinetic equation: F equals Of(1-e^-t/(tau )). The best fit was obtained for a time constant (tau) equals 4.8 min and Of equals 300 J/cm² (correlation coefficient r² equals 0.996). During the first 10 minutes, the fluence required for selective photocoagulation of vessels was increased by a factor 4.5. Conclusion: Fluence required for a selective photocoagulation of vessels was correlated to ICG blood concentration decay. The time constant was equivalent to ICG half-life time in human blood. These results demonstrate that diode laser ICG-enhanced photocoagulation can be controlled by monitoring the ICG blood clearance.

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Thomas Desmettre, Sylvie Soulie-Begu, Jean-Marie Devoisselle, and Serge R. Mordon "Interest of ICG blood clearance monitoring for reproducible 810-nm diode laser coagulation of blood vessels", Proc. SPIE 3564, Medical Applications of Lasers in Dermatology, Cardiology, Ophthalmology, and Dentistry II, (4 February 1999); https://doi.org/10.1117/12.339168

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KEYWORDS

Laser coagulation

Semiconductor lasers

Skin

Blood

Blood vessels

Data modeling

Indocyanine green

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