Type III photosensitization: attempt for quantification and a way toward new sensitizers

Tamas Kriska; Judit Jakus; Agnes Keszler; Rozalia Vanyur; Andras Nemeth; Dezso Gal

doi:10.1117/12.339133

3 February 1999 Type III photosensitization: attempt for quantification and a way toward new sensitizers

Tamas Kriska, Judit Jakus, Agnes Keszler, Rozalia Vanyur, Andras Nemeth, Dezso Gal

Proceedings Volume 3563, Photochemotherapy of Cancer and Other Diseases; (1999) https://doi.org/10.1117/12.339133
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

Earlier results studying the effect of excited triplet photosensitizer on the zymosan-stimulated and luminol- dependent chemiluminescence of macrophages have been quantitatively re-evaluated and rate constant data indicate that the effect is due to triplet-doublet interactions between sensitizer and free radicals generated. Such interactions, named Type III mechanism, compete with Type I and Type II mechanisms depending on the experimental environment. This suggestion resulted in the synthesis of new sensitizers being the first members of the Antioxidant Carrier Sensitizer (ACS) group of molecules. According to preliminary experiments the PDT treatment of tumor bearing mice seems promising with two of such compounds which demonstrate an inhibitory effect in chemical systems already in their ground state.

Citation Download Citation

Tamas Kriska, Judit Jakus, Agnes Keszler, Rozalia Vanyur, Andras Nemeth, and Dezso Gal "Type III photosensitization: attempt for quantification and a way toward new sensitizers", Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); https://doi.org/10.1117/12.339133

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