Experimental study of PDT with aluminum sulphophthalocyanine using sodium ascorbate and hyperbaric oxygenation

Gennadii A. Meerovich; Nadezgda L. Torshina; Victor B. Loschenov; Alexander A. Stratonnikov; Anna I. Volkova; Georgy N. Vorozhtsov; Oleg L. Kaliya; Eugeny A. Lukyanets; Boris Ya. Kogan; Alexander V. Butenin; Eugenia A. Kogan; Olga P. Gladskikh; Larisa N. Polyakova

doi:10.1117/12.339120

3 February 1999 Experimental study of PDT with aluminum sulphophthalocyanine using sodium ascorbate and hyperbaric oxygenation

Gennadii A. Meerovich, Nadezgda L. Torshina, Victor B. Loschenov, Alexander A. Stratonnikov, Anna I. Volkova, Georgy N. Vorozhtsov, Oleg L. Kaliya, Eugeny A. Lukyanets, Boris Ya. Kogan, Alexander V. Butenin, Eugenia A. Kogan, Olga P. Gladskikh, Larisa N. Polyakova

Author Affiliations +

Proceedings Volume 3563, Photochemotherapy of Cancer and Other Diseases; (1999) https://doi.org/10.1117/12.339120
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

It is well known that sulphophthalocyanine derivatives under laser irradiation induce photochemical reaction of II type with generation of cytotoxic agent - singlet oxygen. The combination of phthalocyanine and exogenic reductant - sodium ascorbate may also induce other reactions, involving the formation of free radicals, and thus intensify the antitumor effect. To improve the results of PDT we used the additional injection of sodium ascorbate, the hyperbaric oxygenation and different regimes of laser irradiation. We conducted the experimental study on 100 white mice with Erlich carcinoma. Macroscopic and microscopic data showed that sodium ascorbate significantly increases the effect of PDT in comparison with control group due to the higher tumor damage, vascular alterations, inhibition of cell proliferation and stimulation of antitumor desmoplastic reaction.

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Gennadii A. Meerovich, Nadezgda L. Torshina, Victor B. Loschenov, Alexander A. Stratonnikov, Anna I. Volkova, Georgy N. Vorozhtsov, Oleg L. Kaliya, Eugeny A. Lukyanets, Boris Ya. Kogan, Alexander V. Butenin, Eugenia A. Kogan, Olga P. Gladskikh, and Larisa N. Polyakova "Experimental study of PDT with aluminum sulphophthalocyanine using sodium ascorbate and hyperbaric oxygenation", Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); https://doi.org/10.1117/12.339120

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