Aluminium sulphophthalocyanine as an NIR photosensitizer for PDT

Boris Ya. Kogan; Alexander V. Butenin; Nadezgda L. Torshina; Eugenia A. Kogan; Oleg L. Kaliya; Eugeny A. Lukyanets; Yu. M. Luzhkov; Valentina M. Derkacheva; A. A. Pankratov; Georgy N. Vorozhtsov; Anna I. Volkova

doi:10.1117/12.339131

3 February 1999 Aluminium sulphophthalocyanine as an NIR photosensitizer for PDT

Boris Ya. Kogan, Alexander V. Butenin, Nadezgda L. Torshina, Eugenia A. Kogan, Oleg L. Kaliya, Eugeny A. Lukyanets, Yu. M. Luzhkov, Valentina M. Derkacheva, A. A. Pankratov, Georgy N. Vorozhtsov, Anna I. Volkova

Author Affiliations +

Proceedings Volume 3563, Photochemotherapy of Cancer and Other Diseases; (1999) https://doi.org/10.1117/12.339131
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

It was found that irradiation of aqueous solution of aluminum sulphophthalocyanine (S_nPcAl) by light with wavelength of 805 nm in the presence of sodium ascorbate results in photodynamic type I effect. S₂PcAl in adsorbed state on proteins or polysaccharide structures was shown to possess rather intense long wavelength absorption band in the NIR spectral region. The comparative tests of S_nPcAl with sodium ascorbate on mice with Ehrlich carcinoma and leucosis P-388 showed that photodynamic efficiency in the case of NIR irradiation (790 nm) is not lower than using visible irradiation (675 nm).

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Boris Ya. Kogan, Alexander V. Butenin, Nadezgda L. Torshina, Eugenia A. Kogan, Oleg L. Kaliya, Eugeny A. Lukyanets, Yu. M. Luzhkov, Valentina M. Derkacheva, A. A. Pankratov, Georgy N. Vorozhtsov, and Anna I. Volkova "Aluminium sulphophthalocyanine as an NIR photosensitizer for PDT", Proc. SPIE 3563, Photochemotherapy of Cancer and Other Diseases, (3 February 1999); https://doi.org/10.1117/12.339131

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