Building artificial networks of protein molecular motors

Dan V. Nicolau; Hitoshi Suzuki; Hideo Taniguchi; Takahisa Taguchi; Susumu Yoshikawa; Shinro Mashiko

doi:10.1117/12.293481

14 November 1997 Building artificial networks of protein molecular motors

Dan V. Nicolau, Hitoshi Suzuki, Hideo Taniguchi, Takahisa Taguchi, Susumu Yoshikawa, Shinro Mashiko

Proceedings Volume 3241, Smart Materials, Structures, and Integrated Systems; (1997) https://doi.org/10.1117/12.293481
Event: Far East and Pacific Rim Symposium on Smart Materials, Structures, and MEMS, 1997, Adelaide, Australia

Abstract

This study attempts to assess the feasibility of building purposefully designed molecular motor arrays, the proteins responsible for the movements of the living organisms and cells. The 'building' process used high-resolution e-beam patterning, originating in semiconductor technology, upgraded to make biomicrolithography compatible with the patterning of bioactive molecules. The material used as a scaffold for the array [a copolymer of poly(tert-butyl-methacrylate/methyl- methacrylate)] was tailored to exhibit large difference in hydrophobicity when exposed to e-beam exposure. The e-beam patterning exposure-induced difference in hydrophobicity is responsible for the selective attachment of the myosin molecules on the patterned deep-submicron 'tracks,' and the higher concentration of 'guiding' molecules selectively confines the movement of the actin filaments.

Citation Download Citation

Dan V. Nicolau, Hitoshi Suzuki, Hideo Taniguchi, Takahisa Taguchi, Susumu Yoshikawa, and Shinro Mashiko "Building artificial networks of protein molecular motors", Proc. SPIE 3241, Smart Materials, Structures, and Integrated Systems, (14 November 1997); https://doi.org/10.1117/12.293481

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