Effect of sample compositions on chemical analysis using matrix-assisted laser desorption ionization mass spectrometry

David Schriemer; Yuqin Dai; Liang Li

doi:10.1117/12.259762

26 November 1996 Effect of sample compositions on chemical analysis using matrix-assisted laser desorption ionization mass spectrometry

David Schriemer, Yuqin Dai, Liang Li

Author Affiliations +

Proceedings Volume 2835, Advanced Technologies for Environmental Monitoring and Remediation; (1996) https://doi.org/10.1117/12.259762
Event: SPIE's 1996 International Symposium on Optical Science, Engineering, and Instrumentation, 1996, Denver, CO, United States

Abstract

Matrix-assisted laser desorption ionization (MALDI) is an effective ionization technique for mass spectrometry. It take advantages of some unique properties of certain organic chemicals to provide entrapment, isolation, vaporization, and ionization of the analyte of interest. While the main application of the MALDI technique is currently in the area of biological molecule analysis, it is possible to use this technique for monitoring polymer chemistry such as degradation processes. This is potentially important for studying and developing environmentally degradable polymers. Direct analysis of the analyte in real-world samples is possible with MALDI. However, there is a significant effect of the overall composition of a sample on the detectability and performance of MALDI. Two examples are given to illustrate the positive and negative effects of buffers, salts, and additives on the MALDI sample preparation.

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David Schriemer, Yuqin Dai, and Liang Li "Effect of sample compositions on chemical analysis using matrix-assisted laser desorption ionization mass spectrometry", Proc. SPIE 2835, Advanced Technologies for Environmental Monitoring and Remediation, (26 November 1996); https://doi.org/10.1117/12.259762

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