Primary stage of photodestruction of malignant cells under photodynamic therapy of tumors

Vasili A. Mostovnikov; Galina R. Mostovnikova; Vitali Yu Plavski; Antonina I. Tretjakova

doi:10.1117/12.229492

8 January 1996 Primary stage of photodestruction of malignant cells under photodynamic therapy of tumors

Vasili A. Mostovnikov, Galina R. Mostovnikova, Vitali Yu Plavski, Antonina I. Tretjakova

Proceedings Volume 2728, CIS Selected Papers: Laser Use in Oncology; (1996) https://doi.org/10.1117/12.229492
Event: CIS Selected Papers: Laser Use in Oncology, 1995, -, Russian Federation

Abstract

In this work we present the experimental results indicating that under photodynamic therapy the primary stage of the photodestruction of malignant cells is based on the irreversible photodestruction of glycolysis enzymes located, first of all, in mitochondria playing a key role in the energy supply for the tumor cells. It was shown that the formation of complexes between glycolysis enzymes and a sensitizer promotes an effective destruction of the formers. The formation of strong complexes was demonstrated for a number of glycolysis enzymes (glyceraldehyde-2-phosphate dehydrogenase, pyruvate kinase, lactate dehydrogenase) with the use of water-soluble pigments chlorin e₆ and tetra(carboxyphenyl)porphyrin (T(CP)P) as sensitizers. The direct correlation was shown between the effectiveness of the photodestruction of enzyme molecules and the enzyme-sensitizer binding constant.

Citation Download Citation

Vasili A. Mostovnikov, Galina R. Mostovnikova, Vitali Yu Plavski, and Antonina I. Tretjakova "Primary stage of photodestruction of malignant cells under photodynamic therapy of tumors", Proc. SPIE 2728, CIS Selected Papers: Laser Use in Oncology, (8 January 1996); https://doi.org/10.1117/12.229492

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