New LED source for photodynamic therapy: preclinical study

Martin L. de Jode; Mike G. Dilkes; Michael F. Grahn; Peter B. Hart; Anthony L. Raven

doi:10.1117/12.229531

8 January 1996 New LED source for photodynamic therapy: preclinical study

Martin L. de Jode, Mike G. Dilkes, Michael F. Grahn, Peter B. Hart, Anthony L. Raven

Proceedings Volume 2629, Biomedical Optoelectronics in Clinical Chemistry and Biotechnology; (1996) https://doi.org/10.1117/12.229531
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Preclinical studies of a new light emitting diode light source suitable for photodynamic therapy at 650 nm are described. The light source is found to produce effective cell kill using the colo26 cell line and the photosensitizer m-THPC. The performance of the LED source for PDT in tissue is evaluated in comparison with a copper vapor pumped dye laser by measuring depth of necrosis obtained in normal rat liver. Similar depths of necrosis are obtained. It is concluded that the device shows promise as an alternative light source for photodynamic therapy with m-THPC.

Citation Download Citation

Martin L. de Jode, Mike G. Dilkes, Michael F. Grahn, Peter B. Hart, and Anthony L. Raven "New LED source for photodynamic therapy: preclinical study", Proc. SPIE 2629, Biomedical Optoelectronics in Clinical Chemistry and Biotechnology, (8 January 1996); https://doi.org/10.1117/12.229531

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available